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Leaping Together Toward Sustainable, Patient‐Centered Innovation: The Value of a Multistakeholder Safe Haven for Accelerating System Change

Eric NormanNovember 2, 2018Articles, LEAPS

Clinical Pharmacology & Therapeutics, November 2, 2018Gigi Hirsch Successfully delivering on the promise of emerging science in a world of value-driven healthcare requires that we fundamentally reengineer biomedical innovation processes … Read More

Alternative State-Level Financing for Hepatitis C Treatment—The “Netflix Model”

Eric NormanOctober 29, 2018Articles, FoCUS

JAMA, October 29, 2018Mark R. Trusheim, William M. Cassidy, and Peter B. Bach Drug prices in the United States remain the highest in the world.1 New payment approaches are needed, … Read More

Improving Management of Gene and Cell Therapies: The Orphan Reinsurer and Benefit Manager (ORBM)

Eric NormanSeptember 10, 2018Articles, FoCUS

D. Han; D.S. Mytelka; G.L. Warren; M. Ciarametaro; M. Trusheim. PharmaExec.com, 2018 After decades of anticipation, 2017 saw the approval of the first of a new generation of durable and … Read More

Improving Management of Gene and Cell Therapies

Eric NormanSeptember 10, 2018Articles

Pharmaceutical Executive, September 10, 2018Michael Ciarametaro, Mark Trusheim, Daniel S. Mytelka, Gregory L. Warren, and Donald Han After decades of anticipation, 2017 saw the approval of the first of a … Read More

Adaptive Pathways create win-win scenarios for patients and pharma

Eric NormanMay 1, 2017Adaptive Licensing, Articles

QuintilesIMS, May 2017Jon Resnick In Europe, the concept of ‘adaptive pathways’ offers a faster route to critical medicines for patients with highest unmet needs through an iterative process of early … Read More

Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation

Eric NormanDecember 1, 2016Articles

Clinical Pharmacology & Therapeutics, December 1, 2016R. Stewart, P. W. Barone, A. Bellisario, C. L. Cooney, P. A. Sharp, A. J. Sinskey, S. Natesan, and S. L. Springs Despite the … Read More

Pharmaceuticals Licensing and Reimbursement in the European Union, United States, and Japan

Eric NormanDecember 1, 2016Articles

Clinical Pharmacology & Therapeutics, December 1, 2016A. Oye, H. G. Eichler, A. Hoos, Y. Mori, T. M. Mullin, and M. Pearson This article describes recent developments in licensing and reimbursement … Read More

A Benefit–Risk Analysis Approach to Capture Regulatory Decision-Making: Non-Small Cell Lung Cancer

Eric NormanDecember 1, 2016Articles

Clinical Pharmacology & Therapeutics, December 1, 2016K. Raju, K. Gurumurthi, R. Domike, D. Kazandjian, G. Blumenthal, R. Pazdur, and J. Woodcock Drug regulators around the world make decisions about drug … Read More

Health Technology Assessment in the Context of Adaptive Pathways for Medicines in Europe: Challenges and Opportunities

Eric NormanDecember 1, 2016Adaptive Licensing, Articles

Clinical Pharmacology & Therapeutics, December 1, 2016C. Bouvy, P. Jonsson, C. Longson, N. Crabb, and S. Garner Adaptive pathways for medicines have gained momentum and, in Europe, adaptive pathways have … Read More

“Threshold‐crossing”: A Useful Way to Establish the Counterfactual in Clinical Trials?

Eric NormanSeptember 21, 2016Articles

Clinical Pharmacology & Therapeutics, September 21, 2016Hans-Georg Eichler A central question in the assessment of benefit/harm of new treatments is: how does the average outcome on the new treatment (the … Read More

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CBSD
Center for Biomedical System Design

Our mission is to improve health outcomes by accelerating appropriate, timely, and equitable patient access to biomedical products in ways that work for all stakeholders.

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NEWDIGS Initiative

MIT Center for Biomedical Innovation
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  • About
    • Our approach to innovation
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  • Tufts Medical Center ICRHPS

Tufts Medical Center NEW Drug Development ParadIGmS (NEWDIGS) is an international “think and do tank” dedicated to delivering more value faster to patients, in ways that work for all stakeholders. NEWDIGS designs, evaluates, and initiates advancements that are too complex and cross-cutting to be addressed by a single organization or market sector. Its members include global leaders from patient advocacy, payer organizations, biopharmaceuti-cal companies, regulatory agencies, clinical care, academic research, and investment firms. For more information, visit https://newdigs.tuftsmedicalcenter.org.