Alzheimer's disease
TITLE
The approval of disease-modifying therapies for early, symptomatic Alzheimer's disease is raising hope for patients and caregivers. And promising new therapeutic and diagnostic capabilities are expected in the next five years. Unfortunately, the healthcare system is not prepared to serve all patients who might benefit from these innovations.
This case study focuses on one key leverage point in advancing health system preparedness in the US: reengineering Alzheimer's disease management (detection, diagnosis, and treatment) to be more primary care oriented.
Outputs from this case study include:
- Roadmap 2030, with a particular focus on
transforming early Alzheimer’s disease care - An open access dynamic simulation model of
Alzheimer’ disease for solution design and
implementation planning - Implementation plan for one selected system
solution, demonstrating use of the simulation model - Ongoing communication activities to enhance
visibility and catalyze real-world adoption of solutions
and tools across the global Alzheimer’s ecosystem.
Download the case study (PDF)
Obesity
TITLE
Obesity, first classified as a disease rather than a result of lifestyle choices in 2013, is now an epidemic in the US. While the recent approval of effective drug therapies offers new promise for patients, these alone are not enough for optimal treatment and reversing obesity rate trends.
The Obesity Medicines Project focuses on re-engineering healthcare systems to improve obesity disease management. The scope of the future state vision includes (1) Patient Identification, Engagement, and Diagnosis, (2) Shared Capability Building and (3) Integrated Care.
Outputs from this case study will include:
- Roadmap for Transforming Obesity Disease
Management - Catalyze adoption through dissemination and
discussion with key audiences including
policymakers, professional, advocacy, and
industry groups.
Get the case study
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Publications
Health Affairs Forefront: Bringing Systems Thinking to Drug Value Assessment
March 11, 2025BioCentury OpEd: Biomedical Innovation Requires Health System Innovation
May 21, 2024New team members welcome
We’re seeking founding members of the Precision Access Systems Pilot Network Team. Read more about it here.
About Precision Access Systems
Science is evolving in exciting ways that have the potential to transform health. But too often the healthcare system isn’t ready for these product innovations, undermining our ability to capture their full potential clinical value for patients.
The Precision Access Systems (PAS) Project will help the system catch up with the science of biomedical innovation through:
- System Design Methods focused on streamlining the delivery of the right treatment to the right patient at the right time for a target disease
- Biomedical Health Efficiency metrics to evaluate the impact of the innovations designed in #1 on the performance of the system in capturing product value
Join NEWDIGS
The NEWDIGS consortium is a global “think and do” tank focused on improving health outcomes by accelerating appropriate, timely, and equitable access to biomedical products in ways that are scalable and sustainable for the system.
We tackle challenges that are too big and complex to be addressed by any single organization or stakeholder alone. Join us as we build on our proven multi-stakeholder system design methods to advance the next way of innovation through our Precision Access Systems project.
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NEWDIGS Partners
NEWDIGS partners support the PAS project with financial or in-kind donations. Current partners include:
Eli Lilly & Co.
Johnson & Johnson
Takeda
Population Health Partners
Intellia Therapeutics
Lyfegen
Alexion Pharmaceuticals, Inc.
Sequoia Reinsurance Services, LLC
Metsera
Emerging Therapy Solutions, Inc.