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While the problem of finding system-wide, implementable precision financing models for curative and durable therapies involves all stakeholders, patients and caregivers are directly affected by many different elements of financial burden. Generally, patient and caregiver financial challenges related to their disease and treatment are bracketed by categories that relate to money: outlays, such as co-pays and deductibles, and lost income. Our research revealed more nuanced, wider-reaching challenges, including several under the theme of resource navigation.