LEAPS Design Lab
November 15–16, 2022 at MIT
November 15–16, 2022
Samberg Conference Center, 6th Floor
50 Memorial Drive, Cambridge
Objectives
- Align awareness and understanding of current activities and priorities in LEAPS.
- Advance implementation planning for prototyping of federated learning via the Predictive Outcomes Platform for the NSCLC case study through team meetings and joint team design exercises.
- Explore future directions for LEAPS including a potential new program for scaling generalizable design principles to a range of disease areas.
Welcome
Hello LEAPS Community and Design Lab Family,
Welcome in advance to our upcoming LEAPS Design Lab on Tuesday, November 15th and Wednesday, November 16th! We are excited to once again gather with you in person at the MIT Samberg Conference Center. We are grateful to those of you who joined us for our June 2022 Design Lab (our first in-person event since 2019!) and we also want to extend a very warm welcome to new collaborators to our LEAPS community who are joining us for the first time. We have much to catch up on and consider as we plan our next steps and explore future directions for the LEAPS Project in our new home at the Center for Biomedical System Design at Tufts Medical Center.
We look forward to lively, productive discussions and—most importantly—re-connecting with you in person. As always, we greatly appreciate your ongoing support and commitment. Your input will be critical for our success!
Looking forward to continuing our work together.
Best regards,
Gigi
DAY ONE |
11:00am – 6:30pm |
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11:00am – 12:00pm |
Lunch and registration |
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12:00 – 1:00pm |
Introductions And Frame The Day |
Gigi Hirsch & Mark Trusheim |
1:00 – 1:45pm |
Team Updates |
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Joint IO/Core Protocol |
Gigi Hirsch & Elizabeth Apgar (NEWDIGS) |
Methods Innovation |
Fotios Kokkotos (NEWDIGS) |
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METRICS |
Jane Barlow (NEWDIGS) |
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Precision Reimbursement |
Mark Trusheim |
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1:45 – 3:15pm |
Team meetings |
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3:15 – 3:30pm |
Break |
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3:30 – 4:30pm |
Team Reports and Group Discussion |
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4:30 – 4:45pm |
Wrap-up and Day Two Preview |
Mark Trusheim |
4:45 – 6:30pm |
Reception |
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DAY TWO |
8:00am – 1:00pm |
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8:00 – 9:00am |
Networking breakfast |
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9:00 – 9:30am |
Frame the Day & System Design Connections Overview |
Mark Trusheim & Gigi Hirsch |
9:30 – 11:00am |
Whiteboard Sessions |
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Track A – Predictive Outcomes Platform (POP) |
Facilitators: Gigi Hirsch & Asvin Srinivasan (Onc.AI) |
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Track B – Defining Stakeholder-Specific Thresholds |
Facilitators: Jane Barlow & Mark Trusheim |
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11:00 – 11:15am |
Break |
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11:15 – 11:45am |
Whiteboard Sessions Report Out |
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11:45am – 12:15pm |
Forward Planning |
Gigi Hirsch |
12:15 – 1:00pm |
Networking Lunch (with To Go option) |
Design Lab Pre-Reads
LEAPS Design Lab Briefing November 2022
LEAPS Design Lab Briefing June 2022 (optional)
Day 1 Team Meeting-Specific Pre-Reads
Joint IO/Core Protocol Teams Meeting
Methods Innovation Team
- Draft Methods Innovation Team Data and Technical Skills framework
- Draft Methods Innovation Team Machine Learning and Statistical Methods Outline
- Draft Methods Innovation Team Federated Learning Network Outline
Precision Reimbursement Team Meeting
- FoCUS Project October 2022 Design Lab Briefing Book_abbreviated
- Ratner Prevention of Diabetes in GDM women 2008
- Proceedings of Roundtable Framework
METRICS team
Day 2 Whiteboard Session
Track B: Defining Stakeholder-Specific Thresholds for Outcome Metrics
TIM Tickets instructions
LEAPS Design Lab Tim Ticket Instructions
Parking
There are a few public parking facilities near campus which are available for a fee.
- 7 Cambridge Center Garage – Ames Street between Broadway and Main Streets
This garage is about two blocks away from the Samberg Conference Center.
- Marriott Hotel Garage/Cambridge Center – Between Broadway and Ames Streets
This garage is about two blocks away from the Samberg Conference Center.
- Kendall Square South Garage – 350 Kendall Street
This garage is a 5-10 minute walk from the Samberg Conference Center.
- One Broadway Garage – Enter from Bird Street
This garage is a 5-10 minute walk from the Samberg Conference Center.
- Corner of Massachusetts Avenue and Vassar Street
This is about a 10-15 minute walk from the Samberg Conference Center.
On-street parking near the Samberg Conference Center is extremely rare. Ames Street has limited metered parking and Memorial Drive has free parking, but both are usually full by 8:00 am.
Elizabeth Apgar Nur Azrina Azhar Jane Barlow Paul Beninger Stella Blackburn Dasha Cherepanov Lucas de Breed John Ferguson Jamie Foley Diana Frame Kaitlin Gately Karen Geary Nashadee Guerrier Gigi Hirsch Dorothy Hoffman Keileen Hopps Fotios Kokkotos Smita Kothari Kay Larholt Jacqueline Law Liz Lewis |
Jiaching Lin Mark Lin Peter Loupos Tsega Meshesha Irene Nunes Megan O’Brien Victoria Paly Chris Pashos Silvio Pitter Casey Quinn Kenneth Quinto Gail Ryan Lynn Sanders Eric Small Asvin Srinivasan David Strutton Mark Trusheim Priscilla Velentgas Kate Wallis Wentig Wang Chunlei Zheng |
Chatham House Rule
The Chatham House Rule is used in meetings where participants need a way to openly share information, but don't want to be identified as the source of that information in any meeting records or articles written afterward. The rule is invoked regularly in meetings dealing with sensitive topics. It reads:
“When a meeting, or part thereof, is held under the Chatham House Rule, participants are free to use the information received, but neither the identity nor the affiliation of the speaker(s), nor that of any other participant, may be revealed.”
Antitrust Compliance Statement
Updated November 8, 2022
Tufts Medical Center's NEWDIGS initiative spearheads initiatives focused on re-engineering drug development and delivery processes to optimize access to new medicines for patients while ensuring the sustainability of pharmaceutical innovation. Many of these initiatives involve cooperation among various constituencies, including pharmaceutical companies and other industry stakeholders, patient advocates, healthcare payers, and academic and research institutions.
Because competitors or potential competitors in the marketplace are often participating in the same initiatives, participants in NEWDIGS activities must take care to stay within antitrust boundaries.
The antitrust laws prohibit firms from entering into agreements and engaging in arrangements with competitors that are “anticompetitive” — meaning that they reduce competition more than they advance it. The antitrust laws, however, support and encourage “procompetitive” agreements and arrangements that increase efficiency, enable and improve innovation, and increase the availability of higher quality, lower cost goods and services. NEWDIGS’s initiatives are designed to facilitate “procompetitive” processes.
This Statement provides antitrust guidance to Tufts Medical Center personnel and to the representatives of companies and other institutions who participate in NEWDIGS activities with the goal of encouraging and ensuring antitrust compliance. Even for specially trained experts, it can sometimes be difficult to distinguish “anticompetitive” from “procompetitive” outcomes. This Statement articulates General Antitrust Principles that guide differentiation of various interactions and lists Specific Antitrust Guidelines to enhance the procompetitive nature of NEWDIGS activities and reduce the risk of any inadvertent violation of the antitrust laws. NEWDIGS asks all participants in NEWDIGS activities to follow the General Antitrust Principles and to adhere to the Specific Antitrust Guidelines. The Principles and the Guidelines are intended to be conservative – meaning that they will prohibit some conduct that the antitrust laws may allow – in order to provide a reasonable safety margin for everyone.
General Antitrust Principles
1. Be “antitrust aware”, including in your emails, documents, and conversations. This means remembering that no NEWDIGS activity is intended to reduce competition or create undesirable “anticompetitive” effects. These undesirable effects include increased market power, higher prices, lower quality goods or services, and the creation or strengthening of obstacles to innovation.
2. Part of being “antitrust aware” involves recognizing and memorializing, when appropriate, the desirable “procompetitive” effects that flow from cooperative exploration and innovation. These effects include faster rates of innovation, greater efficiency, increased output, lower prices, and higher quality goods and services. Documents and meeting agendas that identify those positive effects create a helpful contemporaneous record of the participants’ procompetitive vision, which can be consulted later.
3. Note that preserving a particular company’s or group of companies’ prices, profit margins, or position in an industry is not a legitimate goal, particularly in the dynamic industries involved in NEWDIGS’s activities. All companies are expected to succeed on their own merits and not because they have created obstacles to competition. The law establishes one important exception – patent holders possess a temporary, completely legal monopoly as their reward for innovation. A patent holder, acting alone, is entitled to use the legal system to exclude rivals from practicing the subject of the patent.
4. “Market power,” meaning the ability of a single company or group of companies to control the price or availability of goods and services, is rarely permissible under antitrust laws. The acquisition or use of market power is tolerated where it results from superior products, services, or business skill, but otherwise it is highly suspect. No NEWDIGS activity that makes economic sense only if it creates or intensifies market power for the participants (other than through the eventual assertion of patent rights) should be undertaken without first consulting NEWDIGS's compliance contact.
5. Other countries have their own competition regimes, and some of those regimes operate quite differently from the United States’ antitrust laws. Recognizing that much of NEWDIGS’s work may affect the global marketplace, NEWDIGS intends to comply with competition laws in all countries where its work has local effect. This Compliance Statement addresses the fundamental principles that are common to the competition regimes in the United States and the European Union. If you believe a NEWDIGS activity is likely to have a significant, negative economic effect on a company outside of the United States or European Union, please raise that issue with NEWDIGS's compliance contact.
Specific Antitrust Guidelines
1. Do not reach any of the following types of agreements with a competitor: agreements affecting the price at which goods or services are sold in competition; agreements allocating customers or markets among competitors; or agreements not to deal with any company or organization.
2. Do not discuss with a competitor information concerning any of the following: your company’s or your competitors’ prices, costs, discounts, terms of sale, or profit margins or anything else that might affect those prices; the resale prices your customers should charge for any products you sell them; markets, customers, territories, or products sold in competition; whether or not to deal with any other company or organization; or any other competitively sensitive information concerning your company or a competitor. In addition, do not share non-public data concerning these topics with a competitor.
3. Do prepare and follow an accurate agenda, even if only in summary form, for meetings attended by representatives of two or more direct competitors.
4. Do consult with NEWDIGS’s antitrust compliance contact before proceeding in any area of uncertainty. The compliance contact does not provide legal advice. When needed, the compliance contact will obtain legal advice for Tufts Medical Center participants. All non-Tufts Medical Center participants must consult their own counsel for legal advice.
5. Do recognize that the antitrust laws encourage cooperation among competitors for the legitimate, procompetitive purposes envisioned by NEWDIGS. A more detailed look at this complex area may be found in the United States’ Antitrust Guidelines for Collaborations among Competitors, found here.